Technical

MOFgen’s products are based on a class of materials called
Metal Organic Frameworks (MOFs).

MOFs are powdery solids with microscopic pores that can be loaded with biologically active and medically useful agents such as nitric oxide gas (NO) and metal ions. Acting like reservoirs, our MOF products can be incorporated into coatings and formulations to provide slow and controlled release of the active agent(s) over the desired timescale.

MOFs for Biomedical Applications

MOFs are amongst the most exciting new materials to be developed in recent years. They are classed as nanoporous materials and are composed of metal ions connected together by organic (carbon based) molecules (or “linkers”). Through judicious pairing of metal and linker, and with careful control of synthesis conditions, scaffold-like three-dimensional structures are formed that have extremely high porosity and surface area.

MOFen designs MOFs by manipulating their highly tuneable chemistry to build in features that allow storage and controlled release of medically useful agents – such as antimicrobial metal ions and nitric oxide gas. Products can be designed to deliver one or multiple agents depending on the requirements of the application.1

Nitric Oxide

Amongst the agents that MOFgen products can deliver is nitric oxide (NO). This gaseous biological signalling molecule is key to many functions within our bodies including vasodilation, wound healing and controlling platelet adhesion.2-5 NO also has remarkable antimicrobial properties,6 and can disrupt and kill biofilms. Having the ability to controllably deliver NO artificially and enhance the body’s natural mechanisms is very relevant to many healthcare applications.

Being a gas, NO is inherently difficult to handle and administer safely. Indeed, too much NO is very dangerous and toxic; therefore a highly effective and safe method of delivering precise doses over defined time scales is crucial.

MOFgen’s products, when incorporated into coatings and articles, are ideally suited to this role because they show all of the required attributes including high capacities (thanks to their porous structures), delivery of required concentrations, near 100% release and effectiveness over suitable timescales.

Formulating MOFs into your product

Achieving the correct formulation in appropriate matrices is critical to the successful application of MOFs to healthcare products. The technical team at mofgen has over ten years’ experience of incorporating MOF powders into coatings, articles and formulations spanning many different product types, and works closely with its customers to ensure compatibility and optimal performance.

Biomedical MOF supply

MOFgen has developed proprietary methods for the manufacture of its products that remove the historic reliance by MOF researchers on toxic and environmentally undesirable solvents and energetically wasteful conditions. MOFgen manufactures MOFs at scale under cGMP protocols.

  1. McKinlay A C et al., APL Mater. 2, 2014, 124108. Multirate Delivery of Multiple Therapeutic Agents From Metal-Organic-Frameworks.
  2. Ignarro L J et al., Proc. Natl. Acad. Sci. USA,1987, 84, 9265. Endothelium-derived Relaxing Factor Produced and Released From Artery and Vein is Nitric Oxide.
  3. Radomski M W et al., Lancet, 1987, 330, 8567, 1057. Endogenous Nitric Oxide Inhibits Human Platelet Adhesion to Vascular Endothelium.
  4. Kubes P et al., Proc. Natl. Acad. Sci. USA, 1991, 88, 4651. Nitric Oxide: AN Endogenous Modulator of Leukocyte Adhesion.
  5. Risk M, Witte M B and Barbul A, World J. Surg., 2004, 28, 301. Nitric Oxide and Wound Healing
  6. Fang F C, J Clin. Invest., 1997, 99 (12), 2818. Mechanisms of Nitric Oxide-related Antimicrobial Activity
©2017 Copyright - Mofgen Ltd